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KMID : 1134820000290030460
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 3 p.460 ~ p.465
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Effect of Crude Saponin Fraction from Korean Red Ginseng on Physiological Functions of Old Female Rat
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Kwak Yi-Seong
Wee Jae-Joon
Hwang Seok-Yeon
Kyung Jong-Su
Kim Si-Kwan
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Abstract
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This study was carried out to investigate the effect of crude saponin fraction of red ginseng on climacteric disturbances of old rats. The effects of crude saponin fraction of red ginseng were evaluated by using old rat (12 month±1 week), in which climacteric disturbances were considered to be induced spontaneously. The saponin fraction was prepared by Diaion HP-20 adsorption chromatography and spirit. A total of 36 rats were divided into 3 groups : young normal rat (NC), old rat not treated with saponin (NT) and old rat treated with saponin (NS). The body weight of NS group was constant throughout the experimental period, while that of NT group increased 6.2%. The blood sugars, total cholesterol, and blood urea nitrogen in NT group were increased when compared with those of young rats (NC). However, the contents were significantly reduced in NS group (p<0.05, p<0.01). The activities of GOT and GPT in NT group were 202, and 96 IU/L but those of NS group were decreased to 174 and 69 IU/L, respectively, which were almost same levels of NC group. These results suggest that crude saponin fractions of red ginseng improves decline of liver function spontaneously induced by aging.
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KEYWORD
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crude saponin, Korean red ginseng, physiological function, old rat
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